Gene: STK11 ×
Source: CLINVAR ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913319
rs121913319
STK11
TG 0.700 CausalMutation CLINVAR A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. 9428765

1998
dbSNP: rs1131690930
rs1131690930
STK11
TC 0.700 CausalMutation CLINVAR

dbSNP: rs1131690916
rs1131690916
STK11
T 0.700 GeneticVariation CLINVAR Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. 19892943

2009
dbSNP: rs1131690916
rs1131690916
STK11
T 0.700 GeneticVariation CLINVAR Cancer risk associated with STK11/LKB1 germline mutations in Peutz-Jeghers syndrome patients: results of an Italian multicenter study. 23415580

2013
dbSNP: rs1131690917
rs1131690917
STK11
T 0.700 GeneticVariation CLINVAR Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma. 11389158

2001
dbSNP: rs1131690917
rs1131690917
STK11
T 0.700 CausalMutation CLINVAR

dbSNP: rs1131690921
rs1131690921
STK11
T 0.700 CausalMutation CLINVAR

dbSNP: rs1131690923
rs1131690923
STK11
T 0.700 CausalMutation CLINVAR

dbSNP: rs1131690925
rs1131690925
STK11
T 0.700 CausalMutation CLINVAR

dbSNP: rs1131690926
rs1131690926
STK11
T 0.700 CausalMutation CLINVAR

dbSNP: rs1131690940
rs1131690940
STK11
T 0.700 CausalMutation CLINVAR High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome. 16287113

2005
dbSNP: rs1131690940
rs1131690940
STK11
T 0.700 CausalMutation CLINVAR Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome. 9850045

1998
dbSNP: rs1131690940
rs1131690940
STK11
T 0.700 CausalMutation CLINVAR Relative frequency and morphology of cancers in STK11 mutation carriers. 15188174

2004
dbSNP: rs1131690940
rs1131690940
STK11
T 0.700 CausalMutation CLINVAR Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. 16707622

2006
dbSNP: rs1131690940
rs1131690940
STK11
T 0.700 CausalMutation CLINVAR An updated mutation spectrum in an Australian series of PJS patients provides further evidence for only one gene locus. 17026623

2006
dbSNP: rs1131690945
rs1131690945
STK11
T 0.700 CausalMutation CLINVAR

dbSNP: rs121913324
rs121913324
STK11
T 0.700 CausalMutation CLINVAR Relative frequency and morphology of cancers in STK11 mutation carriers. 15188174

2004
dbSNP: rs121913324
rs121913324
STK11
T 0.700 CausalMutation CLINVAR Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. 16707622

2006
dbSNP: rs137853076
rs137853076
STK11
T 0.700 CausalMutation CLINVAR Molecular and clinical characteristics in 46 families affected with Peutz-Jeghers syndrome. 17404884

2007
dbSNP: rs137853076
rs137853076
STK11
T 0.700 CausalMutation CLINVAR Relative frequency and morphology of cancers in STK11 mutation carriers. 15188174

2004
dbSNP: rs137853076
rs137853076
STK11
T 0.700 CausalMutation CLINVAR A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. 9428765

1998
dbSNP: rs1555734904
rs1555734904
STK11
T 0.700 CausalMutation CLINVAR

dbSNP: rs587782018
rs587782018
STK11
T 0.700 CausalMutation CLINVAR Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma. 11389158

2001
dbSNP: rs587782018
rs587782018
STK11
T 0.700 CausalMutation CLINVAR Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. 12865922

2003
dbSNP: rs730881959
rs730881959
STK11
T 0.700 CausalMutation CLINVAR